On Mike Naberezny's blog, there are two new posts for developers working with Zend Studio. In the first post, he describes how to upgrade the PHP interpreter inside Studio that is used for local debugging:

Zend Studio for Windows ships with an "internal" debugger for running your scripts in Studio without a webserver. Studio 4.0.2 ships with PHP 5.0.3. Recently, I encountered a bug in 5.0.3 that was corrected in 5.0.4 and I wanted to upgrade the internal debugger myself rather than wait for the next Studio release. Here's how to do it.

In the second post, Mike gives some background on Studio's remote debugging capabilities, and also gives a tip for faster debugging and profiling:

On both Windows and UNIX-like systems, there is a handy trick that eliminates both the startup latency and the extraneous browser windows. You can set your browser activation command to run cURL instead of your browser.

Mike then describes the method in detail and notes that this can significantly streamline use of the profiler.