In one of his recent posts Alex King looks at three things that most plague WordPress users in their day to day running of their sites - the security of their installation, upgrading when a new version comes out and making good backups of your information just in case.
I often get questions about WordPress security and how best to manage WordPress upgrades. These issues are closely related, and I've thought about them a good deal over the years (and I've been doing this long enough to have experimented with a variety of approaches). These are the approaches I am currently using and recommend for the technically savvy.
For each of the three topics (security, upgrades and backups) he talks a bit about the current situation of it in the WordPress world and offers up some helpful hints to guide you along a good path as well as links to a few services and tools that can help save you when you need that all important file from a backup.